A na-eji polyurethanes eme ihe n'ọtụtụ ebe na ngwa biomedical dị ka akpụkpọ arụrụ arụ, akwa ụlọ ọgwụ, tubes dialysis, ihe ndị na-eme ngwa ngwa, catheters, na mkpuchi ịwa ahụ.The bioocompatibility, mechanical Properties, na ọnụ ala dị ala bụ isi ihe na-eme ka polyurethane nwee ọganihu na ngalaba ahụike.

Mmepe nke implants na-achọkarị ọdịnaya dị elu nke ihe ndị dị ndụ, n'ihi na ahụ na-ajụ ha obere.N'ihe banyere polyurethane, biocomponent nwere ike ịdị iche site na 30 ruo 70%, nke na-emepụta ohere sara mbara maka ngwa na mpaghara ndị dị otú ahụ.2).Polyurethane nke biobased na-abawanye òkè ahịa ha ma na-atụ anya iru ihe dị ka nde $42 site na 2022, nke bụ pasentị pere mpe nke ahịa polyurethane n'ozuzu (ihe na-erughị 0.1%).Ka o sina dị, ọ bụ mpaghara na-ekwe nkwa, na nyocha kpụ ọkụ n'ọnụ na-aga n'ihu gbasara iji ihe ndị ọzọ na-emepụta ihe na polyurethane.Ọ dị mkpa ka emewanyewanye ihe na akụrụngwa nke polyurethane biobased iji kwekọọ n'ihe ndị a chọrọ, iji bulie itinye ego.

A na-emepụta polyurethane kristal biobased site na mmeghachi omume nke PCL, HMDI, na mmiri nke na-arụ ọrụ nke eriri eriri (33).Emere ule nleda anya iji mụọ nkwụsi ike nke biopolyurethane n'ime mmiri anụ ahụ emepụtara, dị ka ngwọta saline nke phosphate buffered.Mgbanwe ndị ahụ

na thermal, mechanical, and physical properties a nyochaa ma jiri ya tụnyere ya

polyurethane nwetara site na iji ethylene glycol dị ka a yinye extender kama mmiri.Nsonaazụ gosipụtara na polyurethane nwetara site na iji mmiri dị ka ihe ndọtị agbụ na-enye ihe ndị ka mma karịa oge ma e jiri ya tụnyere petrochemical.Nke a abụghị nanị na-ebelata nke ukwuu

ọnụ ahịa nke usoro ahụ, ma ọ na-enyekwa ụzọ dị mfe iji nweta ihe ndị na-ahụ maka ahụike bara uru nke kwesịrị ekwesị maka nkwonkwo nkwonkwo (endoprostheses).33).Nke a sochiri ụzọ ọzọ dabere na echiche a, bụ nke mebere urea biopolyurethane site na iji polyol nke sitere na mmanụ rapeseed, PCL, HMDI, na mmiri dị ka ihe ndọtị agbụ.6).Iji mee ka ebe dị elu dị elu, a na-eji sodium chlorine mee ihe iji meziwanye porosity nke polymers ndị a kwadebere.A na-eji polymer synthesized mee ihe dị ka ihe nrịbama n'ihi nhazi ya na-adịghị mma iji mee ka mkpụrụ ndụ na-eto eto nke ọkpụkpụ.N'iji nsonaazụ yiri ya tụnyere

na ihe atụ gara aga, polyurethane nke ekpughere na mmiri mmiri nke simulated gosipụtara nkwụsi ike dị elu, na-enye nhọrọ dị mma maka ngwa scaffold.Polyurethane ionomers bụ klaasị ọzọ na-adọrọ mmasị nke polymers ejiri maka ngwa biomedical, n'ihi ịdị mma ha na mmekọrịta dị mma na gburugburu ahụ.Enwere ike iji polyurethane ionmers dị ka akụrụngwa tube maka ndị na-eme ngwa ngwa na hemodialysis.34, 35).

Mmepe nke usoro nnyefe ọgwụ dị irè bụ mpaghara nyocha dị mkpa nke na-elekwasị anya ugbu a n'ịchọ ụzọ isi kwụsị ọrịa cancer.A kwadoro nanoparticle amphiphilic nke polyurethane dabere na L-lysine maka ngwa nnyefe ọgwụ.36).Nke a nanocarrier

Doxorubicin na-eju ya nke ọma, nke bụ ọgwụgwọ ọgwụ dị irè maka mkpụrụ ndụ kansa (Nyocha 16).Akụkụ hydrophobic nke polyurethane na-emekọrịta ihe na ọgwụ ahụ, na akụkụ hydrophilic na-ejikọta ya na sel.Usoro a mepụtara usoro isi-shell site na nchikota onwe ya

usoro ma nwee ike ibuga ọgwụ nke ọma site n'ụzọ abụọ.Nke mbụ, nzaghachi okpomọkụ nke nanoparticle mere ka ọ bụrụ ihe na-akpali akpali n'ịhapụ ọgwụ na okpomọkụ cell cancer (~ 41-43 Celsius C), nke bụ nzaghachi extracellular.Nke abụọ, akụkụ aliphatic nke polyurethane tara ahụhụ

enzymatic biodegradation site n'omume nke lysosomes, ikwe ka doxorubicin hapụ n'ime cell cancer;Nke a bụ nzaghachi intracellular.Egburu ihe karịrị 90% nke mkpụrụ ndụ kansa ara, ebe a na-edobe cytotoxicity dị ala maka sel ahụike.

Onyonyo 16. Atụmatụ n'ozuzu maka usoro nnyefe ọgwụ dabere na amphiphilic polyurethane nanoparticle

iji nwalee mkpụrụ ndụ cancer. Emegharịrị site na ikike sitere na ntụaka(36).Nwebiisinka 2019 American Chemical

Otu.

Nkwupụta: E si na ya pụtaOkwu Mmalite nke Polyurethane ChemistryFelipe M. de Souza, 1 Pawan K. Kahol, 2 na Ram K.Gupta *,1 .Naanị maka nkwurịta okwu na mmụta, emela ebumnuche azụmahịa ndị ọzọ, anaghị anọchite anya echiche na echiche nke ụlọ ọrụ ahụ, ọ bụrụ na ịchọrọ ibipụtaghachi, biko kpọtụrụ onye edemede mbụ, ma ọ bụrụ na e nwere mmebi iwu, biko kpọtụrụ anyị ozugbo iji wepụ nhazi.